Volume 15, Issue 7 (October 2017)                   Nurs Midwifery J 2017, 15(7): 488-496 | Back to browse issues page

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Atabaki P, Samarei R, Aribi M S, Soheili A, Mehryar H R. A COMPARATIVE STUDY ON THE EFFECT OF TOPICAL PHENYLEPHRINE WITH TOPICAL TRANEXAMIC ACID IN MANAGEMENT OF EPISTAXIS. Nurs Midwifery J. 2017; 15 (7) :488-496
URL: http://unmf.umsu.ac.ir/article-1-3268-en.html
1- Assistant Professor, Dept. of Emergency Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
2- Associate Professor, Dept. of Otolaryngology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
3- Medical Student, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
4- PhD Student in Nursing, Student Research Committee, School of Nursing & Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran
5- Assistant Professor, Dept. of Emergency Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author) , hamidrezamehryar2010@gmail.com
Abstract:   (7018 Views)
Background & Aims: Epistaxis is defined as acute hemorrhage from the nostril, nasal cavity, or nasopharynx. It is a frequent Emergency Department (ED) complaint and often causes significant anxiety in patients and clinicians. Accordingly, this study aimed to compare the administration of topical Phenylephrine with topical Tranexamic Acid (TXA) in management of epistaxis.
Materials & Methods: This double-blind, randomized clinical trial was conducted on 120 patients with epistaxis referred to Imam-Khomeini University in Urmia, Iran. Patients who met the inclusion criteria, were randomly allocated into two intervention and control groups. Sixty patients in the intervention group received one pledget soaked with TXA for 10 minutes in each nasal cavity. Sixty patients in the control group received Phenylephrine 0.5% with the same way. The cessation of bleeding in ED were evaluated by 10 minutes after the administration of the above-mentioned drugs.
Results: Nasal hemorrhage was stopped in 17 out of 60 patients of control group received Phenylephrine (28.3%) while in the intervention group received TXA, 40 out of 60 patients (66.7%) experienced the cessation of their nosebleed that the difference was clinically and statistically significant (P<0.001).
Conclusion: According to study results, topical application of injectable form of TXA (500mg/5mL) can be used as an ideal drug in management of epistaxis in prehospital and hospital settings and subsequently leads to a reduction of extra costs and length of stay in the EDs.
 
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Type of Study: Research | Subject: پزشکی

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