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 Abstract  Background & Aims: Quality of life is an important criterion in indicating the effectiveness of health care. Despite evidence of the effectiveness of self-management interventions in chronic diseases, few studies have been made regarding the value of self-management programs in patients undergoing hemodialysis. The aim of this study was to evaluate the effectiveness of self-management program on the quality of life in patients undergoing hemodialysis.  Materials & Methods: This study is a randomized clinical trial. The sample consisted of 82 patients undergoing hemodialysis admitted to the dialysis ward of Taleghani Hospital. After purposive selection, the patients were randomly assigned to the experimental and control groups. The data were completed 12 weeks before and after of intervention by using the demographic information, and kidney disease quality of life questionnaire. Then they were analyzed by using descriptive statistics, independent samples t-test and paired t test.  Results: The results showed that there was a significant difference between the intervention and control groups in the mean quality of life after the intervention in the aspects of diseases symptoms, the quality of social interactions, encouraging the dialysis unit staff, physical role, pain and emotional role (p

Keywords: self-management, quality of life, dialysis

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