Volume 13, Issue 4 (7-2015)                   Nursing and Midwifery Journal 2015, 13(4): 253-259 | Back to browse issues page

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Ashrafrezaei N, Khadem Ansari M, Sohrabi N. EFFECTS OF HELICOBACTER PYLORI INFECTION ON CATALASE, PROTEIN CARBONYL IN PATIENTS WITH CHRONIC GASTRITIS. Nursing and Midwifery Journal 2015; 13 (4) :253-259
URL: http://unmf.umsu.ac.ir/article-1-2418-en.html
1- Master of Microbial Biotechnology, Tehran University, Instructor of Midwifery, School of Nursing and Midwifery, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author) , nayer_rezaee@yahoo.com
2- Professor of University of Medical Sciences, Urmia, Iran
3- Assistant Professor, Tehran campus of Payam Noor University, Department of Biology
Abstract:   (5535 Views)
 Effects of Helicobacter Pylori infection on catalase, protein carbonyl in patients with chronic gastritis  Received: 4 Feb, 2015 Accepted: 20 May, 2015  Abstract  Background & Aims: Helicobacter pylori is a gram-negative bacterium that causes damage to the stomach lining, and it cause digestive problems. Several mechanisms have been proposed for the pathogenesis such as producing alkaline conditions by urease enzyme and oxidative stress. Oxidative stress is essentially an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants. An important factor for the evaluation of oxidant and antioxidant is the catalase and protein carbonyl content. The aim of this study was to determine the status of these two factors in individuals infected by H. pylori.  Materials & Methods: After sampling and determination of infection status, protein carbonyl and catalase activity were measured. The survey data were analyzed by using spss software.  Results: 68 out of 150 suspected cases were infected with H. pylori. Catalase and protein carbonyl levels were significantly higher in these cases comparing to the controls.  Conclusions: Increased protein carbonyl content confirms oxidative damage by H. pylori, and catalase activity increases in response to the stress and oxidative damage.  KeyWords: Gastritis, Catalase Protein carbonyl, Helicobacter Pylori   Address: School of Nursing and Midwifery, Urmia University of Medical Sciences, Urmia, Iran  Tel: (+98)4432754961-4  Email: nayer_rezaee@yahoo.com
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Type of Study: Research | Subject: پزشکی

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