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Received: 21 Nov, 2015 Accepted: 21 Jan, 2016 Abstract Background &  Aims: Gastrointestinal side effects are among the most common side effects of chemotherapy on the compliance of the patient. Therefore, understanding the symptoms and how to prevent them in the process of the treatment and prevention of recurrent hospitalization can be highly helpful. This study aimed to study the effect of mothers' empowerment on their children's gastrointestinal side effects. Materials & Methods: This study is a Quasi-experimental nonequivalent control group design which was carried out in Dr Sheikh Hospital in Mashhad in 2013. Empowerment program was in three empowerment sessions with focus on its complications: nausea, vomiting, diarrhea, constipation, and loss of appetite which were trained on experimental group. The program was developed and based on the process of empowerment as conceptualized by Gibson’s theory program, composing 4 steps. To gather the data, standard questionnaires on chemotherapy side effects were applied in three stages of before, during and after the intervention. For data analysis, SPSS software, version 18 was used. Results: Average side effects in intervention group after the intervention were lower than the control group. Nausea from 53/7% to 26/3%, vomiting from 66/7% to 33/3%, diarrhea from 50% to 10%, constipation from 33/6% to 6/7% and loss of appetite from 93/3% to 36/7% were decreased respectively in the intervention group, and significant differences were seen) p

Keywords: Gastrointestinal, Chemotherapy, Child, empowerment, mothers

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