Background & Aims: Schizophrenia is a complex mental disorder that has the severest and the most destructive effect on the quality of life persons. Undoubtedly, the use of anti-psychotic medicine is the core and basis of schizophrenia treatment. The aim of this study is to determine the effect of adherence to treatment intervention program on the quality of life schizophrenic patients. Materials & Methods: This is a clinical trial where 70 schizophrenia patients of hospitalized were randomly divided into two intervention and control groups in Razi Medical-Educational Center, Urmia. Data was collected using schizophrenic quality of life scale questionnaire (SQLS). The intervention group underwent educational intervention in the form of six lecture and discussion sessions conducted twice a week, each lasting for 30-60 minutes. The collected data of pre and post intervention was analyzed using SPSS16 as well as descriptive statistics, chi-square test, non-parametric test, Mann-Whitney test, Fisher test and dependent-t test. Results: According to analyses, there was no significant difference in the mean score of quality of life between the two groups (P =0/280). However, after the intervention, the quality of life in the intervention group improved significantly (P< 0/001). In the beginning of the study, the overall mean score of quality of life in the intervention group was (68/88±24/13). However, at the end of the study it was (42/08±20/25) while the overall mean score in the control group in the beginning and at the end of the study was (66/20±18/74) and (61/20±18/48), respectively (P

Keywords: Compliance therapy, training, quality of life, schizophrenia

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