Background & Aim: In order to improve patient safety were forced to strengthen the safety of monitoring systems. It is also necessary to reform its weaknesses and to develop it among the staff. This study aimed to determine the status of patient safety culture in the Medical Center of Imam Reza in Tabriz and factors affecting it. Methods & Materials: This study is a descriptive-correlational research. The study population included surgical nurses. The data collection instrument included Hospital Survey on Patient Safety Culture. To analyze the data, descriptive statistics and independent t-tests, ANOVA, Pearson correlation coefficient and multivariate linear regression analysis were employed using SPSS V20 statistical software. Results: In the dimensions of patient safety culture, the highest mean scores are related to dimensions of organizational learning- continuous improvement, support of hospital management of safety and general perception of safety culture, and the lowest mean scores are related to dimension of teamwork between organizational units, matters related to employees and non-punitive response to errors. Pearson correlation test results in age (P

Keywords: Hospital, Nurses, Patient Safety, Safety Culture

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