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Background & Aims: Entry to the university is a gigantic change in the students’ lives and the increase in the assignments and homework pressures, the other peer students’ influence, the increase in popularity and easy access to the drugs causes them to become inclined to the drug use. The psychological health and hygiene of the students as the elites of the society is among the worries and concerns of the planners and decision-makers in a macro level. Thus, the current descriptive-analytical research aims at determining the factors contributing to the drug use in Urumia’s Medical Sciences University. Materials & Methods: The present cross-sectional study has been carried out based on a descriptive-analytical method. The study sample volume includes 538 Urmia’s Medical Sciences University undergraduate students. The sampling was undertaken in multiple stages. To gather the required information, a researcher-made questionnaire was administered to the study subjects. The face validity of the questionnaire was conducted via inquiring six specialist professors for their corrective ideas and the questionnaire’s reliability was determined by taking advantage of test-retest method. The data were analyzed by means of SPSS software, ver.23. Descriptive statistical tests were applied to characterize the data and chi-square test was utilized to investigate the relationship between the various variables exerting an influence on the drug abuse. Results: The results indicated that 28.3% of the university students had addictions to cigarettes and narghile, 12.5% of them were addicted to alcoholic drinks and 14.7% were drug abusers. Among the factors influencing the drug use, affective failures (57.7%), psychological-mental pressures (54.9%), feeling the lack of parents’ love (36%), loneliness (32.6%), relieving pain (30%), seeking pleasure (26.8%) and purposelessness (25%) were most prevalent. Moreover, Chi-square test showed a significant relationship between smoking and hookah with gender and residence status, between alcohol consumption with gender, family economic status, residency and field of study, and between addictive drug abuse and economic status of the family, residency status, and field of study (p

Keywords: Drug Abuse, risk factor, Medical Sciences University Students

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