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Background & Aims: Labor pain is one of the most severe pains and is an inevitable part of childbirth. Considering the global policy of reducing selective cesarean section and the need for effective and safe methods to reduce labor pain, this study was conducted to evaluate and summarize the results of clinical trials conducted on the effect of various pain relief methods by systematic review. Materials & Methods: In this review article, all relevant studies from the databases of the Clinical Trials Registry, Magiran, Medlib, SID, IranMedex, Scopus, Google Scholar, and PubMed using the keywords labor pain, reducing labor pain, pain relief, clinical examination, labor pain, pain relief, clinical trial, pain, and birth were searched without time limit and 165874 articles were extracted. Subsequently, 53 clinical trials that were based on the severity of a score of 3 or more and fit the criteria of the study were included. Data analysis was performed qualitatively. Results: The results showed that among all the interventions Lavender, Golab, Entonox, Acupressure, Reflexology resulted in the highest reduction in labor pain. Conclusion: Lavender, Golab, Entonox, Acupressure, Reflexology were effective methods for relieving or reducing labor pain. Judging the definitive effectiveness of these interventions require extensive research with higher sample sizes and strongmethodology.

Keywords: Labor pain, Clinical trial, Reduction of labor pain, Labor pain relief

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