Volume 19, Issue 3 (June 2021)                   Nursing and Midwifery Journal 2021, 19(3): 233-242 | Back to browse issues page

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Rezaee S, Choobdari A. PREVALENCE OF RISK FACTORS DURING PREGNANCY IN AUTISM SPECTRUM DISORDERS. Nursing and Midwifery Journal 2021; 19 (3) :233-242
URL: http://unmf.umsu.ac.ir/article-1-4376-en.html
1- Assistant Professor, Department of Psychology and Education of Exceptional Children, Allameh Tabataba'i University, Tehran, Iran (Corresponding Author) , rezayi.saeed10@gmail.com
2- Department of Psychology and Education of Exceptional Children, Allameh Tabataba'i University, Tehran, Iran
Abstract:   (1915 Views)
Background & Aims: Autism spectrum disorder is one of the most common forms of pervasive developmental disorders and it is introduced as one of the most serious and unrecognized disorders in childhood. Therefore, the aim of this study was to determine the prevalence of the risk factors during pregnancy for autism spectrum disorders. Materials & Methods: The sample size was 310 subjects (109 girls and 201 boys) who were selected using the available sampling method. The researcher collected information using The International Classification of Functioning, Disability and Health (ICF). Visual analysis and percentage index were used to analyze the data. Results: Factors such as maternal disease, drug use during pregnancy, maternal seasonal sensitivity, second child, single child, prematurity, jaundice during pregnancy, triple vaccination, MMR vaccine, history of NICU and incubator, maternal bleeding in the first trimester of pregnancy, gestational diabetes, history of the ruptured bladder during pregnancy, history of thyroid, Maternal overweight, history of varicose veins during pregnancy, history of nausea, having surgery during pregnancy, stress during pregnancy, cesarean delivery, unwanted pregnancy, iron deficiency during pregnancy, family relationship, family problems, phototherapy, and neonatal overweight were identified. According to the percentage index, MMR vaccine history with 91% and diabetes during pregnancy with 27% had the highest and lowest prevalence, respectively. Conclusion: Findings from this study showed that some factors during pregnancy are more common in children with the autism spectrum disorder. Therefore, effective preventive therapy and treatment can be considered. It is also suggested that experts and officials in this field plan related screenings.
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1. Association AP. Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub; 2013. [URL]
2. Khanna R, Madhavan SS, Smith MJ, Patrick JH, Tworek C, Becker-Cottrill B. Assessment of health-related quality of life among primary caregivers of children with autism spectrum disorders. J Autism Dev Disord 2011;41(9):1214-27. [DOI:10.1007/s10803-010-1140-6] [PMID]
3. Rezaei S. Autism disorder. From diagnosis to treatment. Tehran: Avae Noor Publications; 2014. [URL]
4. Christensen J, Gronborg TK, Sørensen MJ, Schendel D, Parner ET, Pedersen LH, et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA 2013;309(16):1696-703. [DOI:10.1001/jama.2013.2270] [PMID] [PMCID]
5. Baxter AJ, Brugha T, Erskine HE, Scheurer RW, Vos T, Scott JG. The epidemiology and global burden of autism spectrum disorders. Psychol Med 2015;45(3):601. [DOI:10.1017/S003329171400172X] [PMID]
6. Gau SS-F, Chou M-C, Chiang H-L, Lee J-C, Wong C-C, Chou W-J, et al. Parental adjustment, marital relationship, and family function in families of children with autism. Res Autism Spectr Disord 2012;6(1):263-70. [DOI:10.1016/j.rasd.2011.05.007]
7. Lai M-C, Lombardo MV, Suckling J, Ruigrok AN, Chakrabarti B, Ecker C, et al. Biological sex affects the neurobiology of autism. Brain 2013;136(9):2799-815. [DOI:10.1093/brain/awt216] [PMID] [PMCID]
8. Karst JS, Van Hecke AV. Parent and family impact of autism spectrum disorders: A review and proposed model for intervention evaluation. Clin Child Fam Psychol Rev 2012;15(3):247-77. [DOI:10.1007/s10567-012-0119-6] [PMID]
9. Ronald A, Hoekstra RA. Autism spectrum disorders and autistic traits: a decade of new twin studies. Am. J. Med. Genet. B: Neuropsychiatr. Genet 2011;156(3):255-74. [DOI:10.1002/ajmg.b.31159] [PMID]
10. Bailey A, Le Couteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E, et al. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med 1995;25(1):63-77. [DOI:10.1017/S0033291700028099] [PMID]
11. Van Wijngaarden-Cremers PJ, van Eeten E, Groen WB, Van Deurzen PA, Oosterling IJ, Van der Gaag RJ. Gender and age differences in the core triad of impairments in autism spectrum disorders: a systematic review and meta-analysis. J Autism Dev Disord 2014;44(3):627-35. [DOI:10.1007/s10803-013-1913-9] [PMID]
12. Neal AP, Guilarte TR. Molecular neurobiology of lead (Pb 2+): effects on synaptic function. Mol Neurobiol 2010;42(3):151-60. [DOI:10.1007/s12035-010-8146-0] [PMID] [PMCID]
13. Gardener H, Spiegelman D, Buka SL. Prenatal risk factors for autism: comprehensive meta-analysis. Br J Psychiatry 2009;195(1):7-14. [DOI:10.1192/bjp.bp.108.051672] [PMID] [PMCID]
14. Newschaffer CJ, Fallin D, Lee NL. Heritable and nonheritable risk factors for autism spectrum disorders. Epidemiol Rev 2002;24(2):137-53. [DOI:10.1093/epirev/mxf010] [PMID]
15. Atladóttir HÓ, Henriksen TB, Schendel DE, Parner ET. Autism after infection, febrile episodes, and antibiotic use during pregnancy: an exploratory study. Pediatrics 2012;130(6):e1447-e54. [DOI:10.1542/peds.2012-1107] [PMID] [PMCID]
16. Lee BK, Magnusson C, Gardner RM, Blomström Å, Newschaffer CJ, Burstyn I, et al. Maternal hospitalization with infection during pregnancy and risk of autism spectrum disorders. Brain Behav Immun 2015;44:100-5. [DOI:10.1016/j.bbi.2014.09.001] [PMID] [PMCID]
17. Fang SY, Wang S, Huang N, Yeh HH, Chen CY. Prenatal infection and autism spectrum disorders in childhood: A population‐based case-control study in T aiwan. Paediatr Perinat Epidemiol 2015;29(4):307-16. [DOI:10.1111/ppe.12194] [PMID]
18. Zerbo O, Iosif A-M, Delwiche L, Walker C, Hertz-Picciotto I. Month of conception and risk of autism. Epidemiology 2011;22(4):469. [DOI:10.1097/EDE.0b013e31821d0b53] [PMID] [PMCID]
19. Gentile S. Prenatal antidepressant exposure and the risk of autism spectrum disorders in children. Are we looking at the fall of Gods? J Affect Disord 2015;182:132-7. [DOI:10.1016/j.jad.2015.04.048] [PMID]
20. Carpita B, Muti D, Dell'Osso L. Oxidative stress, maternal diabetes, and autism spectrum disorders. Oxid Med Cell Longev 2018;2018. [DOI:10.1155/2018/3717215] [PMID] [PMCID]
21. Beversdorf DQ, Stevens HE, Jones KL. Prenatal stress, maternal immune dysregulation, and their association with autism spectrum disorders. Curr Psychiatry Rep 2018;20(9):1-12. [DOI:10.1007/s11920-018-0945-4] [PMID] [PMCID]
22. Shelton JF, Tancredi DJ, Hertz‐Picciotto I. Independent and dependent contributions of advanced maternal and paternal ages to autism risk. Autism Res 2010;3(1):30-9. https://doi.org/10.1002/aur.135 [DOI:10.1002/aur.116] [PMID] [PMCID]
23. Lee L-C, Harrington RA, Louie BB, Newschaffer CJ. Children with autism: Quality of life and parental concerns. J Autism Dev Disord 2008;38(6):1147-60. [DOI:10.1007/s10803-007-0491-0] [PMID]
24. Maleki T, Kazemi Y. Application of the International Functional Classification Framework (ICF) Framework for Intervention for Speech and Language Disorders in Preschool Children: A Systematic Review. J Rehabil Sci 2015;11(6 ):425-32.
25. Kinney DK, Munir KM, Crowley DJ, Miller AM. Prenatal stress and risk for autism. Neurosci Biobehav Rev 2008;32(8):1519-32. [DOI:10.1016/j.neubiorev.2008.06.004] [PMID] [PMCID]
26. Rossignol DA, Genuis SJ, Frye RE. Environmental toxicants and autism spectrum disorders: a systematic review. Transl Psychiatry 2014;4(2):e360-e. [DOI:10.1038/tp.2014.4] [PMID] [PMCID]
27. Tomeny TS, Barry TD, Bader SH. Birth order rank as a moderator of the relation between behavior problems among children with an autism spectrum disorder and their siblings. Autism 2014;18(2):199-202. [DOI:10.1177/1362361312458185] [PMID]
28. Ghozy S, Tran L, Naveed S, Quynh TTH, Zayan AH, Waqas A, et al. Association of breastfeeding status with risk of autism spectrum disorder: A systematic review, dose-response analysis and meta-analysis. Asian J Psychiatr 2020;48:101916. [DOI:10.1016/j.ajp.2019.101916] [PMID]
29. Cheng J, Eskenazi B, Widjaja F, Cordero JF, Hendren RL. Improving autism perinatal risk factors: A systematic review. Med Hypotheses 2019;127:26-33. [DOI:10.1016/j.mehy.2019.03.012] [PMID]
30. McDonagh MS, Matthews A, Phillipi C, Romm J, Peterson K, Thakurta S, et al. Depression drug treatment outcomes in pregnancy and the postpartum period: a systematic review and meta-analysis. Obstet Gynecol 2014;124(3):526-34. [DOI:10.1097/AOG.0000000000000410] [PMID]
31. Avella-Garcia CB, Julvez J, Fortuny J, Rebordosa C, García-Esteban R, Galán IR, et al. Acetaminophen use in pregnancy and neurodevelopment: attention function and autism spectrum symptoms. Int J Epidemiol 2016;45(6):1987-96. [DOI:10.1093/ije/dyw115] [PMID]

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