en پرستاری Nursing پژوهشي Research <span style="font-family:Times New Roman;"><span style="font-size:12pt"><span style="line-height:115%"><b>Background</b> This study aimed to investigate the relationship between religiosity and spirituality with anxiety, depression, and stress levels among nursing students at Urmia University of Medical Sciences.</span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><b>Methods</b> The present study was a descriptive-analytical and cross-sectional study. The statistical population consisted of 200 undergraduate nursing students at Urmia University of Medical Sciences in the academic year 2024. Male and female students were selected via simple random sampling. Data were collected using the Khodayari Fard Religious Attitude Questionnaire, Hall and Edwards Spirituality Questionnaire, Depression, Anxiety, and Stress Scale (DASS-21) Questionnaire, and a demographic characteristics questionnaire. Data analysis was performed using descriptive statistics and SPSS software (version 22.0).</span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><b>Results</b> Results demonstrated a significant inverse relationship between religiosity and spirituality and levels of anxiety, depression, and stress (p < 0.001). Students with higher levels of religiosity and spirituality reported lower levels of anxiety, depression, and stress.</span></span><br> <span style="font-size:12pt"><span style="line-height:115%"><b>Conclusion</b> The results of this study can help better understand the impact of religiosity and spirituality on students&rsquo; mental health and provide strategies to improve their mental well-being. These results can be a basis for policies and educational and support programs in universities to reduce anxiety, depression, and stress in students. Thus, the results of this study can be used to improve students&rsquo; mental health and increase the scientific community&rsquo;s awareness of the importance of religiosity and spirituality.</span></span></span><br> &nbsp; Anxiety, Depression, Religiosity, Stress, Student 49 56 http://unmf.umsu.ac.ir/browse.php?a_code=A-10-1628-2&slc_lang=en&sid=1 Mohammad Yousefi Asl YousefiAsl@gmail.com 100319475328460040851 100319475328460040851 No Urmia University of Medical Sciences Rahim Baghaei r.Baghaei@gmail.com 100319475328460040852 100319475328460040852 No School of Nursing and Midwifery, Patient Safety Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Iran Jafar Javan Hoshyar Hoshyarjafar@yahoo.com 100319475328460040853 100319475328460040853 Yes Department of Islamic Studies, School of Medicine, Urmia University of Medical Sciences, Iran Vahid Alinejad alinejad.v@umsu.ac.ir 100319475328460040854 100319475328460040854 No Department of Community Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran MahMonir Haghighi mm.Haghighi@gmail.com 100319475328460040855 100319475328460040855 No Department of Psychiatry, School of Medicine Razi University Hospital, Urmia University of Medical Sciences, Urmia, Iran Ghazaleh Gholami GhazalehGholami@gmail.com 100319475328460040856 100319475328460040856 No School of Nursing and Midwifery, Patient Safety Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Iran