Abstract  Background & Aims: Many patients with chronic renal failure undergo dialysis to survive their illness. Since this is a chronic and debilitating disease, patients are prone to multiple psychiatric consequences. Depression and anxiety are the most common disorders. Physical, psychological, social problems are brought to light in regards to the patient's ability to perform activities and self-efficacy in achieving a good quality of life.  The purpose of this study is to examine relationships among self-care self-efficacy, anxiety and depression in 160 patients receiving hemodialysis.  Materials & Methods: This is an analytical-descriptive study that was done on 160 patients under hemodialysis treatment, and they were selected randomly in educational - therapeutic centers of Rasht city, Iran, in 2011. The data were collected by using four questionnaires of demographic information, Hospital Anxiety Depression Scale (HADS‌), and General Self Efficacy Scale (GSES). The data were analyzed by SPSS 17 soft ware by applying Pearson correlation test, t-test, and analysis variance linear regression. (p

Keywords: self-efficacy, anxiety, depression, hemodialysis, chronic renal failure, nursing

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