Volume 13, Issue 3 (khordad 2015)                   Nursing and Midwifery Journal 2015, 13(3): 246-252 | Back to browse issues page

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shirpour A, Rezaei F, Abolahzadeh Fard A, Tagizadeh Afshari A L. GINGER HYDRO-ALCOHOLIC EXTRACT AMELIORATES THE ALCOHOL-INDUCED KIDNEY DYSFUNCTION IN RAT. Nursing and Midwifery Journal 2015; 13 (3) :246-252
URL: http://unmf.umsu.ac.ir/article-1-2467-en.html
GINGER HYDRO-ALCOHOLIC EXTRACT AMELIORATES THE ALCOHOL-INDUCED KIDNEY DYSFUNCTION IN RAT
Alireza Shirpour1 , Farzaneh Rezaei1 , Amin Abolahzadeh Fard1 , A. li Tagizadeh Afshari * 2
1- Department of Physiology, Faculty OF Medicine, Urmia University of Medical Sciences Urmia, Iran
2- Department of Nephrology, Emam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author) , atafshari@yahoo.com
Abstract:   (9037 Views)
 Ginger Hydro-Alcoholic Extract ameliorates the alcohol-induced kidney dysfunction in rat  ShirpoorAR[1], RezaeeF[2], AbdollahzadeFardA[3], TaghizadehA[4]*  Received: 18 Jan, 2015 Accepted: 21 Apr, 2015  Abstract:  Background & Aims:Chronic alcohol administration decreases the renal tubular reabsorption and induces renal dysfunction. The association between alcohol consumption and renal function, however, is not very well known. The principal aim of this study was to investigate the effects of chronic ethanol consumption on the functions of the kidney and the possible modification of this effect by ginger extract.  Materials &Methods: Twenty-four male wistar rats were divided into three groups namely: Control, ethanol (4.5 gr/kg BW by gavaj), and ginger extract treated ethanolic groups (4.5 gr/kg ethanol along 50 mg of ginger extract). Cystatin c, urea and creatinine in plasma were measured after 42 days.  Results: The results revealed that there was a significant decrease in glomerular filtration rate (GFR) and also significant increase in plasma creatinine, urea and cystatin c in ethanol group compared to the control group. Ginger extract treatment improved kidney disfunction induced by ethanol and it may be due to the ginger antioxidant properties.  Conclusion: Ginger extract ameliorate kidney dysfunction induced by alcohol.  Key Words: Ginger, CystatinC, Ethanol, Createnin, Glumerolarfilteration rate.  Address: Department of Nephrology, Emam Khomeini Hospital, Urmia University of Medical Sciences, Urima, Iran  Tel: (+98)4433469931  Email: atafshari@yahoo.com     [1]Department of Physiology, Faculty OF Medicine, Urmia University of Medical Sciences Urmia, Iran       [2]Department of Physiology, Faculty OF Medicine, Urmia University of Medical Sciences Urmia, Iran       [3]Department of Physiology, Faculty OF Medicine, Urmia University of Medical Sciences Urmia, Iran       [4]Department of Nephrology, Emam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran (Corresponding Author)      
Keywords: Ginger, CystatinC, Ethanol, Createnin, Glumerolarfilteration rate.
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Type of Study: Research | Subject: پزشکی
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