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Background & Aims: To the correct orientation of computer networks hospital information and its approval by healthcare workers can lead to improve the quality of health care services, and reduce costs related to it. The aim of this study was to collect and analyze the nurses' attitudes, motivations and thoughts on the implementation of hospital information system and to determine the use of computerized hospital information system in the process care and treatment of patients in the AmirAlmomenin and Imam Khomeini hospitals of Zabol city in 2014-2015. Materials & Methods: Sectional-descriptive study was conducted on 246 nurses. Because the numbers of community were so low, the census method was used. The data collection tool was a questionnaire whose validity was confirmed by four professors in this field and its reliability was assessed using Cronbach's alpha coefficient. After collecting and entering data into the computer by spss statistical software and descriptive and inferential methods was Spearman test. Results: a direct and positive  relationship  between the two variables  impression  of  being  useful  information technology  and easy  to use the system of basic components  hospital  Information  Technology Acceptance Model,  but  the factors influencing  acceptance of  information  technology. (Pvalue

Keywords: Hospital Information System, Nurse, Technology Acceptance Model

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