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ADVERSE REACTIONS OF STREPTOKINASE IN PATIENTS WITH OR WITHOUT HYDROCORTISONE INJECTION Nasiri M*1 , Rahimian B2, Bashiri T 3, Salmalian F4 Received: 25 April, 2010 Accepted: 27 July, 2010 Abstract Background & Aims: Streptokinase is one of the most useful drugs in acute myocardial infarction. Researches show that timely given injection of streptokinase decreases total mortality. Allergic reaction and bleeding are possible side effects. This research was aimed to determine the adverse reactions of streptokinase in patients with or without hydrocortisone- injection in Ramsar and Tonekabon hospitals in 2007-2008. Materials & Methods: In this quasi-experimental study simple random sampling method was used in CCU wards in Ramsar's Imam Sajjad and Tonkabone Shahid Rajaei hospitals. The patients were divided in two groups (those using and not using hydrocortisone). The data were collected with a demographic questionnaire and a check list. Descriptive- analytical statistics (chi-square) were used and the data were analyzed by SPSS software and. Results: The findings showed in groups using hydrocortisone, fever and chill was %3.33, fever 3.33%, chill 1.67%, vomiting, nausea , chill 1.67%, and PVC 53.3%. In the group not using hydrocortisone chill was 5%, fever 5%, and PVC 50%. There was no significant association between side effects with dependent variable. Conclusion: There was no significant difference in side effects between the group using the hydrocortisone and the other group. Considering serious side effects that may be happen after streptokinase injection, it is necessary to have regular check-ups. Keywords: Streptokinase, Hydrocortisone, Acute myocardial infarction Address: Fateme Zahra Nursing and Midwifery Faculty, Ramsar University of Medical Sciences, Ramsar, Iran Tel: (+98 911)3937671 Email: m.nasiri132@yahoo.com

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