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Introduction: Hemodialysis patients are faced with several stressors such as physical, mental and social stressor and their quality of life that affected with these factors so that their life style, family situation, jop and social situation will change and they don't hope to their future. The main problem in these patients that make their quality of life more complication is coping strategies and there reaction are different from complete ability regain to suicid. This research has done For, determining quality of life, stressor factors and coping strategies in hemodialysis patients in Ramsar and Tonekabon hospital in 1385. Materials and Methods: This research is a descriptive-cross sectional study.The community of research included all hemodialysis patients Ramsar and Tonekabon hospital. This research had done on 42 patientsin. The data gathering instrucment consisted of a four-parts 1.demographic characteristics 2.questionnaires related to quality of life 3. Questionnaire of stressor factors and coping qoestionaire. Descriptive-analytical statistics (Independent T-test,analysis variance and chi-squar)were used. Results: Findings show that most of the samples were women (61.9%), between 57-67 years old (27.6%), Illetrate (59.5%), unable to pay expenditure of life (47.6%)and have dialysis history for 1 years(33.3%). In most of sample,quality of life in general physical aspect and general quality of life were in low level ordinary(90.5%)and 61.9%)and for main human activity aspect in mid level(45.2%),for physical and mental stressor in low level(88.1%and 64.3%),for social aspect in high level (45.2%),for the problem strategies in low level(54.8%)and the emotional focused strategies were used(83%). Statistic test between general physical situation and main human activity with occupation, and quality of life with life expenditure was significant (ordinary P

Keywords: quality of life, coping strategies, Stressor factors, hemodialysis

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