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Introduction: Intravenous immune globulin (IVIG) treatment in isoimmune hemolytic jaundice has been shown to be effective. In this study two dose administration method of therapy was researched. Materials & Methods: In this study, the effect of two doses IVIG therapy was investigated in 56 babies who had ABO and Rh hemolytic disease. At admission all cases’ serum level of bilirubin was in range o f phototherapy treatment. Patients were divided into two groups. Groups Ι (cases=28) received two dose IVIG treatment plus phototherapy, group ΙΙ(control=28) received just phototherapy. Exchange transfusion rate, reduction of serum bilirubin levels and duration of phototherapy were compared between two groups. Results:  Mean ages, weight, bilirubin level, hemoglobulin, hematocrite, reticulocyte, hospitalization days, exchange transfusion and reduction of bilirubin level were 2.35±1.25, 3.07.±2.5 days (p=0.19), 3026±305.95, 3152. ±295 grams (p=0.1), 17.62±2.38, 16.65±2.55mg/dc (p=0.14), 12.42 ± 1.21, 12.35±1.9 gram/dc  (p=0.68), 36.58±4.5, 36.78±5.7percent (p=0.88), 5.6±2, 4.5±2.7percent (p=0.1), 2.8±1.3, 3.6±1.3 days (p=0.33), 0.0, 2.0  (p=0.002)and 7.9±0.46, 1.39±0.27mg/dl (p=0.021)  for control and case group respectively. Conclusion: in spite of that baseline characteristics were similar in two groups there was significant difference at outcome of index. Regard to results of this study it was concluded that two doses IVIG treatment reduces the need of exchange transfusion and lowers serum bilirubin levels in neonatal isoimmune hemolytic jaundice.

Keywords: Jaundice, Hemolytic diseas, IVIGT, Term babies

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