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Introduction: Now a day, high - risk behavior prevalence in youth are the most concern of the human society. Many of these behavior cause a large number of death and injury among Teens, or have negative Impact on society(e.g. ,chemical stimulant & recreational drug use , Alcohol and substances use, high-risk sexual behavior(AIDs) and …) therefore this study was carried out  with aim of  Developing adolescent girls health status with education of sexual high-risk behavior prevention (HIV) in Uremia University of medical Science.Materials and methods: This study is a Semi-experimental research .The sample were student (N=300 girls) that study in Nursing& Midwifery faculty and Para Medicine Uremia University of medical Science. Samples were selected by Random. Data was gathered by a questionnaire that included two parts, first was demographic characters and scound part were questions about the sexual high-risk behavior. We used content validity and reliability test-retest one .The data was analyzed with descriptive statistic (T-Test).Result: Data of this study showed That mean Knowledge of student about high-risk  behavior prevention before teaching 64.70 was increased after teaching to 71.24  with MD= 6.53 . In order to assess of mean difference, we used paired T-Test that showed there was significant deference (t=-10.33, df =21, p

Keywords: girls health, high-risk behavior

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