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Received: 9 Jul, 2015 Accepted: 20 Sep, 2015 Background & Aims: Cancer as a chronic and life-threatening diseases needs a strong resilience capacity. Evaluating the effectiveness of interventions on promoting resilience in adolescents with cancer requires appropriate tools to measure this concept. This study is conducted to evaluate psychometric properties of the Persian version of "Conner-Davidson Resilience Scale" in adolescents with cancer. Materials & Methods: This study is a methodological research to evaluate the psychometric properties of the Persian version of "Conner-Davidson Resilience Scale" (CD-RISC) in adolescents with cancer who attended in clinics and oncology wards in Children's Medical Center of Tehran, clinics and oncology wards in hospitals of Urmia, Children's Medical Center of Tabriz and the Cancer Research Center of Isfahan. Content validity index based on the opinions of 10 experts, was calculated. Construct validity (confirmatory factor analysis), was composed in sample of 200 adolescents with cancer and Cronbach's alpha and correlation coefficients were calculated between the two tests within 3 weeks. Data were analyzed by SPSS version 20 and AMOS version 21. Results: Assessment of Content validity about the scale with no changes in the number and content of the statement was not performed. The confirmatory factor analysis by removing items 2 "is at least one of my close associations with him in times of stress (stress) to help me," five-factor model of the scale was confirmed. Internal consistency for "Conner-Davidson Resilience Scale" &alpha=0/82 and for each of the subscales including Personal competence and self-sufficiency (&alpha =0/75), tolerance of negative effect and strengthening effects to stress (&alpha =0/72), positive acceptance of change (&alpha =0/74), Self -control (&alpha =0/73) and Spiritual influences (&alpha =0/75) were calculated. The Pearson correlation coefficient between the two test results r =0/404 (p

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