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Received: 28 Dec, 2015 Accepted: 1 Mar, 2016 Abstract Background & Aims: Hyperlipidemia is a risk factor that caused and exacerbated cardiovascular disease. There are several different diets and chemical and herbal medicines for correction and reduction of hyperlipidemia. This study investigated the effect of grape seed extract on lipid profile and blood pressure in patients with borderline hyperlipidemia. Materials & Methods: This study was a randomized double-blind clinical trial with before and after design, in which 88 patients with borderline hyperlipidemia were matched by their age, sex, blood lipid profile, and they were randomly allocated to one of the two intervention groups (2 capsules containing 100 mg of grape seed extract) or control (2 placebo). They consumed drug or placebo for 6 weeks. To control the effect of diet on measuring variables three consecutive days before the start of supplementation and two days at the end of the study, 24 Hour Reminder Food questionnaire was completed by the subjects. Lipid profile and blood pressure were analyzed before and after treatment.  Results: In the intervention group oxidized LDL was significantly reduced and HDL was increased (p

Keywords: Grape seed extract, Hyperlipidemias, blood pressure, Cardio metabolic Risk, CVD Risk Factors

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