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Background & Aims: Drug use is one of the international community problems that leads to lose of huge national assets, and is one of the most important factors disturbing security and discipline in the society. Injection is one of the most harmful ways of drug use. About 200 million drug addicts and 11-21 million common people have had drug injection worldwide in 2008. Abuse drug Injection is one of the main reasons of transmitting of infectious diseases such as: AIDS and hepatitis through high-risk behavior. The aim of this study is to evaluate the effect of health education and promotion, and interactive behavior on changing risky behaviors among drug injecting users. Materials & Methods: This quasi-experimental study was carried out to evaluate the effect of education and health promotion intervention on 75 drug injecting users who were selected by convenience sampling in the addiction reduction center of Urmia in 2007-2008. In this study, a self constructed questionnaire was used that contained questions about healthy and risky behaviors. In addition to health education for 4-2 week sessions throughout the year, a healthy package containing syringes, condoms, sterile water and alcohol pad, and a range of amenities such as nutrition, hygiene and bathing accessories, offering free medical care, free psychological counseling, and free social work were also given to abusers. Before and after intervention, data were analyzed by SPSS18 software and statistical tests such as frequency, percentage, mean and standard deviation and paired t-test were also analyzed. Results: The findings showed that the effects of education and health promotion were significant on changing the risky behaviors among drug injecting users. The average scores of before and after intervention had statistically significant difference (P

Keywords: Education, Interactive behavior, High-risk behaviors, Injecting drug use, Drape in Center (DIC)

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