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Background & Aim: female infertility is a problem that affects almost every aspect of women's lives. Infertile women usually experience Psychological problems. Therefore, this research aimed to study comparison of effect of Iranian – Islamic positive therapy with acceptance and commitment therapy on psychological well-being of infertile women in Isfahan city. Materials & Methods: This research was a three- group quasi-experimental study with a pretest-posttest and three- month follow-up. 45 infertile women referring to Isfahan Fertility and Infertility Center selected by purposeful sampling and randomly assigned to experimental and control groups (ACT, IIPT, control). The data collection tool was Ryff Psychological Well-being Questionnaire (PWBQ). Data were analyzed using repeated measures analysis of variance, one-way ANOVA, and Bonferroni test. Results: in the post-test, there was significant difference between experimental groups (Iranian – Islamic positive and ACT) with the control group at psychological well-being (p0/05). In the follow up, there was significant difference between Iranian – Islamic positive group and control group at psychological well-being (p0/05).Also In the follow up, there wasn't significant difference between Iranian – Islamic positive group and ACT group (p>0/05). Conclusions: After the treatment period, in short- term, Both of Iranian – Islamic positive therapy and acceptance and commitment therapy (ACT) in increasing psychological well-being were effective, so that, there was significant difference between experimental groups with control group, whereas there wasn't significant difference between two experimental groups. in the three-month follow-up period, in long-term, treatment outcomes related to psychological well-being in Iranian – Islamic positive group was maintained, but in ACT treatment outcomes related to psychological well-being was not maintained.

Keywords: Iranian – Islamic Positive Therapy, Acceptance and Commitment Therapy, psychological well-being, Infertile Women

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