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Background & Aims: Hysterectomy means the removal of the uterus with or without cervix or ovaries (ovophorectomy). Today, for the treatment of many benign and malignant diseases, elective hysterectomy is performed. Hysterectomy is a heavy and invasive surgical technique that has serious side effects on female sexual characteristics and causes physical disorientation and other factors. It may also be a strong stimulant to stress and psychological problems in women. In this study, we investigated the effect of hysterectomy on the mental and sexual status of patients after surgery. Materials & Methods: Patients aged 30 to 55 years who underwent a non-malignant elective hysterectomy in 2017 and lived with their spouse, were not menopause and had no major stress or history of psychiatric problems in the 6 months before and after surgery were selected. The Beck and FSFI questionnaires were completed for patients 6 months after surgery. The demographic characteristics, the number of children, the age of the patients and their spouses, the cause of hysterectomy, the status of oophorectomy, and chronic abdominal pain were recorded and the statistical data were analyzed using SPSS (version 23). Results: Results showed a significant difference in Beck score between two groups of patients who underwent bilateral oophorectomy and the other group who had one or two ovaries preserved (p = 0.002). Therefore, ovarian preservation was effective in reducing depression. For chronic abdominal pain 6 months after hysterectomy, significant differences existed between the patients with chronic abdominal pain and patients without abdominal pain (P = 0.007). There was no significant difference between duration of hospitalization and depression (P = 0.13). The results showed that there is a significant relationship between depression in housewives and working patients (P=0.027). Concerning the age of the spouse, a positive relationship existed between the age of spouse and depression based on Beck score (P = 0.001). Also, elective hysterectomy had no effect on depression (P = 0.147). The mean FSFI preoperatively for patients was 21.14 with a standard deviation of 10.14 and a mean FSFI after surgery of 16.42 with a standard deviation of 7.8, indicating a decrease in depression. Paired t-test also showed a significant decrease in sexual function after hysterectomy (p

Keywords: Hysterectomy, Depression, Sexual function, Ovophorectomy

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