Volume 10, Issue 2 (6-2012)                   Nursing and Midwifery Journal 2012, 10(2): 0-0 | Back to browse issues page

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Pourheydar B, Joghataei M T, Najafzadeh N. ENHANCED NEUROPATHIC PAIN FOLLOWING INTRASPINALY INJECTION OF SCHWANN CELLS IN CONTUSION MODEL OF SPINAL CORD INJURY. Nursing and Midwifery Journal 2012; 10 (2)
URL: http://unmf.umsu.ac.ir/article-1-820-en.html
Abstract:   (7732 Views)
  Enhanced neuropathic pain following intraspinaly injection of Schwann cells in contusion model of spinal cord injury     Pourheydar B [1] *, Joghataei MT [2] , Najafzadeh N [3]     Received: 6 Nov , 2011 Accepted: 20 Jan , 2012     Abstract   Background & Aims : Spinal cord injury (SCI) leads to sensorimotor deficits and neuropathic pain (NP). Cell therapy is a common method for treatment of SCI. The mechanism which has been explained for development of NP including: transplantation of stem cell leads to differentiation of these cells to astrocytes, and these cells secretes NGF which leads to axonal sprouting in dorsal horn neurons and this leads to NP. Since Schwann cells (SCs) are commonly used in cell therapy, we sought to investigate whether intraspinaly injection of these cells develop NP.   Materials & Methods : 24 male Wistar rats were used. SCs were cultured, model of SCI was performed and rats were divided into the three groups including: a control group, an experiment group and a sham group. In control group only a laminectomy was performed, the experiment group received SCs intraspinaly. The sham group received serum in the same way. Locomotion was assessed using BBB test and NP was assessed by withdrawal threshold test.   Result : Significant improvement was observed in the BBB scores in experiment group (P
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Type of Study: Research | Subject: پرستاری

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