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  The Effect of perforan on the mood symptoms of Premenstrual syndrome     KHeirkhah M [1] ,Abassinia K [2] *,Jahdi F [3] ,Aghahosseini F [4] ,Hassani M [5]     Received: 14 Feb , 2013 Accepted: 17 Apr , 2013    Abstract   Background & Aims : Premenstrual syndrome is a group of cyclic symptoms that occur during the luteal phase of the menstrual cycle.  Materials & Methods : The study was a randomized, double blinded, placebo- controlled trial, with two treatment group. The students of this study are divided randomly into two groups of Perforan group (480 mg) and placebo control group. All the students in this study took drugs during three subsequent cycles so that each person took two capsules daily in the first cycle for one month. In the second and third cycles, they took the drugs from eight days before menstruation to two days after it, and they recorded the severity of the symptoms of her menstruation in the questionnaire of the symptoms.  Result : The results showed a reduction of symptoms in treatment drug group comparing to the placebo. So that the mean severity was reported 23.64 in the Perforan group, and 46.37with (p=0.001) in the placebo group.   Conclusion: Mean severity of mood symptoms premenstrual syndrome has showed that Perforan can reduce the mood symptoms of premenstrual syndrome more than the placebo group.   Keywords: Perforan , Premenstrual syndrome ,Mood symptoms    Address: Faculty of Nursing and Midwifery, Tehran University of Medical Sciences, Department of Midwifery Education   Tel: (+98) 9131851723   Email: K-abbasinya@razi.tums.ac.ir   [1] Faculty of Nursing and Midwifery, Tehran University of Medical Sciences  [2] MSc of Midwifery, Faculty of Nursing and Midwifery, Tehran University of Medical Sciences (Corresponding Author)*  [3] Faculty of Nursing and Midwifery, Tehran University of Medical Sciences, Manager of Midwifery  [4] Instructor of Biostatistics, Faculty of Management and Medical Information Science, Tehran University of Medical Sciences  [5] MSc of Midwifery, Faculty of Nursing and Midwifery, Tehran University of Medical Sciences

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