Volume 13, Issue 7 (Mehr 2015)                   Nursing and Midwifery Journal 2015, 13(7): 596-604 | Back to browse issues page

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Naghizadeh S, Azari S, Fathnejad Kazemi A, Ebrahimpour Mirzarezaei M, Alizadeh S. Assessing and comparing result of amniocentesis and tripel marker tests to detection of Aneuploidies.. Nursing and Midwifery Journal 2015; 13 (7) :596-604
URL: http://unmf.umsu.ac.ir/article-1-1768-en.html
Assessing and comparing result of amniocentesis and tripel marker tests to detection of Aneuploidies.
Somayyeh Naghizadeh * 1, Sahar Azari2 , Azita Fathnejad Kazemi2 , Mehdi Ebrahimpour Mirzarezaei3 , SHarifeh Alizadeh3
1- Tabriz Branch, Islamic Azad University, Tabriz, Iran.(Corresponding Author) , somayyehnaghizadeh@gmail.com
2- Tabriz Branch, Islamic Azad University, Tabriz, Iran.
3- Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:   (12210 Views)
Background & Aims: Antenatally detected of congenital abnormalities can prevent the bearing of abnormal newborns that can create big problems for family and society. The aim of this study was comparing the results of amniocentesis and triple marker tests. Materials & Methods: This is a descriptive study which carried out in 2013. The participants in this study consisted of 205 pregnant women at 15–20 weeks of pregnancy. The result of Down syndrome and other Aneuploidy screening were high in these patients who referred to Alzahra hospital of Tabriz for amniocentesis. A questionnaire including demographic, Down syndrome and triple marker test information was used for data collection. Independent-Samples T-Test, Pearson test and One- Way ANOVA were used for data analysis by applying SPSS /ver 13. Results: The findings indicated that the mean (SD) age of participants was 33.9 ±4. AFP in 139 (68.5%) was lower than 1 MOM, Total &betahcg in 68 (33.4%) was higher than 2 MOM, UE3 in 133 (65.5%) was lower than 1 MOM and Inhibin in 29 (31.2%) was higher than 2 MOM. Aneuploidy was detected in 11 newborns (10 down syndrome, 1 Klinefelter's syndrome).There were significant relationship between risk of Down syndrome and amniocentesis result (P= 0.0001). There weren't significant relationship between NTD and trisomy 18 to amniocentesis result (P&ge 0.05). There were significant relationship between age (P= 0.03), number of delivery (P= 0.04), number of children (P= 0.03) and prior abnormal child (P= 0.001) and amniocentesis results. Conclusion: The results showed that the screening in first trimester can detected 11 newborns of aneuploidies and it can prevent the stress of family, and invasive techniques (amniocentesis).So we can use this way as a routine screening method.
Keywords: Screening, Amniocentesis, Aneuploidy, Down syndrome.
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Type of Study: Research | Subject: مامایی
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