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Received: 27Nov , 2013 Accepted: 27 Jan , 2014   Abstract Background & Aims:  A substantial part of the emotional life of women are biological rhythms. One of the factors related to biological rhythms and sexuality, is premenstrual syndrome (PMS). This study examined the effects of fluoxetine on menstrual symptoms of PMS focuses on high school girls. Materials & Methods: This study is an experimental one with a pretest-posttest control group. The study population consisted of all high school students in Kermanshah. A sample size of 32 was selected as cluster sampling. Questionnaires were distributed among students. After the questionnaires were collected from 16 patients, 32 were randomly divided into two groups of experimental group and control group. The control group received no intervention. Result:  Data analysis showed that consumption of 20 mg fluoxetine for two months in the high school girls with pre menstrual dysphoric syndrome, can reduce the symptoms significantly (001/0> P). Conclusion: According to the results, we can say Fluoxetine is effective in reducing the symptoms of pre-menstrual. Fluoxetine can maintain physical and mental health of girls with this syndrome.

Keywords: Fluoxetine, pre-menstrual dysphoric syndrome, daughter

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