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DETERMINING THE QUQLITY OF CIPROFLOXACINE IN PHARMACEUTICAL FORMULATIONS (TABLETS, EYE DROPS AND INFUSION SOLUTIONS) USING HPLC METHOD WITH FLUORESCENCE DETECTION Akbari A , Heydari A * Received: 5 Apr, 2014 Accepted: 7 Jun, 2014 Abstract Background & aims: Quality control of medicinal products, especially considering the amount of active ingredient of toxic side effects, and their complications is important. The present study was performed to measure Ciprofloxacine which is commercially available in the drug market of Iran. Materials & Methods: In this study pharmaceutical dosage form of Ciprofloxacine with different brands and dosage forms was prepared from a local pharmacy. High Performance Liquid Chromatography (HPLC) was used as the preferred analytical tool. The method uses a C18column. The mobile phase consisted of acetonitrile/ phosphate buffer with (pH= 3) (20:80) and fluorescence detection at 338 and 425 nm. Results:The results of these experiments showed a linear standard curve for Ciprofloxacine over the range of 0.1-2.5 µg/ml. The corresponding regression equation was H= 4.8247 C + 0.8094 with an r2 value of 0.9925. Taking one of the bulk samples as 100% references, the determined content was 209-309 µg/ml for infusion solutions of 200 µg/ml, 0.25-0.027 µg/ml for eye drops of 0.3 µg/ml, 280-701mg for tablets of 250 mg and 511-947 mg for tablets of 500 mg. Conclusion: These findings confirm the necessity of quality and accurate controls over the industrial pharmaceutical companies. Keywords: Ciprofloxacine, HPLC, Pharmaceutical dosage form Address: Faculty of Pharmacy, Urmia University of Medical Sciences, Tel: (+98)441 2754991 Email: heydari.866@gmail.com

Keywords: Ciprofloxacine, HPLC, Pharmaceutical dosage form

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