Volume 19, Issue 11 (Februery 2022)                   Nursing and Midwifery Journal 2022, 19(11): 867-877 | Back to browse issues page


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Hejazi F S, Farshbaf Khalili A, Mahdipour M, Abbasalizadeh F, Shahnazi M. RELATIONSHIP BETWEEN THE SERUM LEVELS OF FOLIC ACID WITH THE RESULTS OF FIRST TRIMESTER DOWN SYNDROME SCREENING METHODS AND FETAL KARYOTYPE IN HIGH RISK PREGNANT WOMEN REFERRING TO THE ALZAHRA EDUCATIONAL HOSPITAL OF TABRIZ. Nursing and Midwifery Journal 2022; 19 (11) :867-877
URL: http://unmf.umsu.ac.ir/article-1-4530-en.html
1- Stem Cell Research Center and Department of Midwifery, Students' Research Committee, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran
2- Aging Research Institute, Physical medicine and rehabilitation Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran
3- Stem Cell Research Center, Tabriz University of Medical Sciences and Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
4- Assistant Professor, Department of Obstetrics and Gynecology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5- Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran (Corresponding author) , mshahnazi@tbzmed.ac.ir
Abstract:   (1349 Views)
Background & Aims: To investigate associations between serum levels of folic acid with the results of the first trimester Down syndrome screening methods and fetal karyotype in high-risk pregnant women. Materials & Methods: In this cross-sectional study, serum levels of folic acid in 232 high risk pregnant women were measured using ELISA method and Down syndrome screening was done using karyotyping. Statistical analysis was done applying multivariate logistic regression by backward strategy tests. Results: In our study, 97% of participants consumed folic acid serum level measurements revealed that 6.9% of participants had low folic acid levels and 5.6% of Down syndrome positive screenings had positive karyotype. Based on the results of multivariate logistic regression test, NT (Nuchal Translucency) (OR: 4.72, [4.01-11.07]) and husband age (OR: 1.23, [1.05-1.43]) were the predictors of fetal Down syndrome karyotype in high-risk pregnant women. There were no significant relationships between serum folic acid levels and any of the Down syndrome karyotype results (p>0.05). Conclusion: These findings demonstrate that serum folic acid concentration is not the predictive marker of Down syndrome karyotype in high risk pregnant women who have positive Down syndrome screening through double marker test.
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Type of Study: Research | Subject: مامایی

References
1. Hu H, Jiang Y, Zhang M, Liu S, Hao N, Zhou J, et al. A prospective clinical trial to compare the performance of dried blood spots prenatal screening for Down's syndrome with conventional non-invasive testing technology. Exp Biol Med 2017; 242(5):547-53. [DOI:10.1177/1535370216683837] [PMID] [PMCID]
2. Ke W-L, Zhao W-H, Wang X-Y. Detection of fetal cell-free DNA in maternal plasma for Down syndrome, Edward syndrome and Patau syndrome of high risk fetus. Int J Clin Exp Med 2015;8(6):9525-30. [PMID] [PMCID]
3. Gekas J, Langlois S, Ravitsky V, Audibert F, van den Berg DG, Haidar H, et al. Non-invasive prenatal testing for fetal chromosome abnormalities: review of clinical and ethical issues. Appl Clin Genet 2016; 9:15. [DOI:10.2147/TACG.S85361] [PMID] [PMCID]
4. System CPS, Rusen ID. Congenital anomalies in Canada: a perinatal health report, 2002: Canadian Perinatal Surveillance System; 2002. [URL]
5. Down syndrome 2013. Available from: https://meshb.nlm.nih.gov/record/ui?ui=D004314. [URL]
6. Alldred, Kate S, Takwoingi, Yemisi, Guo, Boliang, et al. First and second trimester serum tests with and without first trimester ultrasound tests for Down's syndrome screening. Cochrane Database of Systematic Reviews [Internet]. 2017; (3). [DOI:10.1002/14651858.CD012599] [PMID]
7. Irving CA, Chaudhari MP. Cardiovascular abnormalities in Down's syndrome: spectrum, management and survival over 22 years. Arch Dis Child 2012; 97(4):326-30. [DOI:10.1136/adc.2010.210534] [PMID]
8. Nicolaides KH, Syngelaki A, Gil M, Atanasova V, Markova D. Validation of targeted sequencing of single-nucleotide polymorphisms for non-invasive prenatal detection of aneuploidy of chromosomes 13, 18, 21, X, and Y. Prenat Diagn 2013;33(6):575-9. [DOI:10.1002/pd.4103] [PMID]
9. Baluja-Conde IB, Rodríguez-López MR, Zulueta-Rodríguez O, Ruiz-Escandón B, Bermúdez-Velásquez S. Biochemical serum markers for Down syndrome screening. Rev Biomed 2005;16(4):259-72. [DOI:10.32776/revbiomed.v16i4.427]
10. Zampieri BL, Biselli JM, Goloni-Bertollo EM, Vannucchi H, Carvalho VM, Cordeiro JA, et al. Maternal risk for Down syndrome is modulated by genes involved in folate metabolism. Dis Markers 2012;32(2):73-81. [DOI:10.1155/2012/693864] [PMID] [PMCID]
11. Migliore L, Migheli F, Coppede F. Susceptibility to aneuploidy in young mothers of Down syndrome children. ScientificWorldJournal 2009;9:1052-60. [DOI:10.1100/tsw.2009.122] [PMID] [PMCID]
12. folic acid 2016. Available from: https://meshb.nlm.nih.gov/record/ui?ui=D005492.
13. Coppedè F. Risk factors for Down syndrome. Arch Toxicol 2016;90(12):2917-29. [DOI:10.1007/s00204-016-1843-3] [PMID]
14. Trissler RJ. Folic acid and Down syndrome. J Acad Nutr Diet 2000;100(2):159. [DOI:10.1016/S0002-8223(00)00048-1] [PMID]
15. Takamura N, Kondoh T, Ohgi S, Arisawa K, Mine M, Yamashita S, et al. Abnormal folic acid-homocysteine metabolism as maternal risk factors for Down syndrome in Japan. Eur J Nutr 2004;43(5):285-7. [DOI:10.1007/s00394-004-0472-4] [PMID]
16. Boduroglu K, Alanay Y, Koldan B, Tuncbilek E. Methylenetetrahydrofolate reductase enzyme polymorphisms as maternal risk for Down syndrome among Turkish women. Am J Med Genet A 2004;127a(1):5-10. [DOI:10.1002/ajmg.a.20432] [PMID]
17. Green NS. Folic acid supplementation and prevention of birth defects. J Nutr 2002;132(8 Suppl):2356s-60s. Epub 2002/08/07. PubMed PMID: 12163692. [DOI:10.1093/jn/132.8.2356S] [PMID]
18. Duncan TM, Reed MC, Nijhout HF. The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model. Mol Nutr Food Res 2013; 57(4):628-36. [DOI:10.1002/mnfr.201200125] [PMID] [PMCID]
19. Baggot PJ, Eliseo AJ, DeNicola NG, Kalamarides JA, Shoemaker JD. Organic acid concentrations in amniotic fluid found in normal and Down syndrome pregnancies. Fetal Diagn Ther 2008; 23(3):245-8. [DOI:10.1159/000116749] [PMID] [PMCID]
20. Norwitz ER, Levy B. Noninvasive prenatal testing: the future is now. Rev Obstet Gynecol 2013;6(2):48-62. [PMID] [PMCID]
21. Shiefa S, Amargandhi M, Bhupendra J, Moulali S, Kristine T. First Trimester Maternal Serum Screening Using Biochemical Markers PAPP-A and Free β-hCG for Down Syndrome, Patau Syndrome and Edward Syndrome. Indian J Clin Biochem 2013; 28(1):3-12. [DOI:10.1007/s12291-012-0269-9] [PMID] [PMCID]
22. Czeizel AE, Puho E. Maternal use of nutritional supplements during the first month of pregnancy and decreased risk of Down's syndrome: case-control study. Nutrition 2005;21(6):698-704; discussion 74. [DOI:10.1016/j.nut.2004.10.017] [PMID]
23. Hollis ND, Allen EG, Oliver TR, Tinker SW, Druschel C, Hobbs CA, et al. Preconception folic acid supplementation and risk for chromosome 21 nondisjunction: a report from the National Down Syndrome Project. Am J Med Genet A 2013; 161 a(3):438-44. [DOI:10.1002/ajmg.a.35796] [PMID] [PMCID]
24. Tsuji A, Noguchi R, Nakamura T, Shibata K. Folic Acid Deficiency Does Not Adversely Affect Oocyte Meiosis in Mice. Journal of nutritional science and vitaminology.2016; 62(6):375-9. [DOI:10.3177/jnsv.62.375] [PMID]
25. Balduino Victorino D, de Godoy MF, Goloni-Bertollo EM, Pavarino ÉC. Genetic Polymorphisms Involved in Folate Metabolism and Maternal Risk for Down Syndrome: A Meta-Analysis. Dis Markers 2014; 2014:517504. [DOI:10.1155/2014/517504] [PMID] [PMCID]
26. Coppedè F. The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects. Front Genet 2015; 6:223. [DOI:10.3389/fgene.2015.00223] [PMID] [PMCID]
27. Cuckle HS. Primary prevention of Down's syndrome. Int J Med Sci 2005; 2(3):93-9. [DOI:10.7150/ijms.2.93] [PMID] [PMCID]

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