1. Hu H, Jiang Y, Zhang M, Liu S, Hao N, Zhou J, et al. A prospective clinical trial to compare the performance of dried blood spots prenatal screening for Down's syndrome with conventional non-invasive testing technology. Exp Biol Med 2017; 242(5):547-53. [
DOI:10.1177/1535370216683837] [
PMID] [
PMCID]
2. Ke W-L, Zhao W-H, Wang X-Y. Detection of fetal cell-free DNA in maternal plasma for Down syndrome, Edward syndrome and Patau syndrome of high risk fetus. Int J Clin Exp Med 2015;8(6):9525-30. [
PMID] [
PMCID]
3. Gekas J, Langlois S, Ravitsky V, Audibert F, van den Berg DG, Haidar H, et al. Non-invasive prenatal testing for fetal chromosome abnormalities: review of clinical and ethical issues. Appl Clin Genet 2016; 9:15. [
DOI:10.2147/TACG.S85361] [
PMID] [
PMCID]
4. System CPS, Rusen ID. Congenital anomalies in Canada: a perinatal health report, 2002: Canadian Perinatal Surveillance System; 2002. [
URL]
5. Down syndrome 2013. Available from: https://meshb.nlm.nih.gov/record/ui?ui=D004314. [
URL]
6. Alldred, Kate S, Takwoingi, Yemisi, Guo, Boliang, et al. First and second trimester serum tests with and without first trimester ultrasound tests for Down's syndrome screening. Cochrane Database of Systematic Reviews [Internet]. 2017; (3). [
DOI:10.1002/14651858.CD012599] [
PMID]
7. Irving CA, Chaudhari MP. Cardiovascular abnormalities in Down's syndrome: spectrum, management and survival over 22 years. Arch Dis Child 2012; 97(4):326-30. [
DOI:10.1136/adc.2010.210534] [
PMID]
8. Nicolaides KH, Syngelaki A, Gil M, Atanasova V, Markova D. Validation of targeted sequencing of single-nucleotide polymorphisms for non-invasive prenatal detection of aneuploidy of chromosomes 13, 18, 21, X, and Y. Prenat Diagn 2013;33(6):575-9. [
DOI:10.1002/pd.4103] [
PMID]
9. Baluja-Conde IB, Rodríguez-López MR, Zulueta-Rodríguez O, Ruiz-Escandón B, Bermúdez-Velásquez S. Biochemical serum markers for Down syndrome screening. Rev Biomed 2005;16(4):259-72. [
DOI:10.32776/revbiomed.v16i4.427]
10. Zampieri BL, Biselli JM, Goloni-Bertollo EM, Vannucchi H, Carvalho VM, Cordeiro JA, et al. Maternal risk for Down syndrome is modulated by genes involved in folate metabolism. Dis Markers 2012;32(2):73-81. [
DOI:10.1155/2012/693864] [
PMID] [
PMCID]
11. Migliore L, Migheli F, Coppede F. Susceptibility to aneuploidy in young mothers of Down syndrome children. ScientificWorldJournal 2009;9:1052-60. [
DOI:10.1100/tsw.2009.122] [
PMID] [
PMCID]
12. folic acid 2016. Available from: https://meshb.nlm.nih.gov/record/ui?ui=D005492.
13. Coppedè F. Risk factors for Down syndrome. Arch Toxicol 2016;90(12):2917-29. [
DOI:10.1007/s00204-016-1843-3] [
PMID]
14. Trissler RJ. Folic acid and Down syndrome. J Acad Nutr Diet 2000;100(2):159. [
DOI:10.1016/S0002-8223(00)00048-1] [
PMID]
15. Takamura N, Kondoh T, Ohgi S, Arisawa K, Mine M, Yamashita S, et al. Abnormal folic acid-homocysteine metabolism as maternal risk factors for Down syndrome in Japan. Eur J Nutr 2004;43(5):285-7. [
DOI:10.1007/s00394-004-0472-4] [
PMID]
16. Boduroglu K, Alanay Y, Koldan B, Tuncbilek E. Methylenetetrahydrofolate reductase enzyme polymorphisms as maternal risk for Down syndrome among Turkish women. Am J Med Genet A 2004;127a(1):5-10. [
DOI:10.1002/ajmg.a.20432] [
PMID]
17. Green NS. Folic acid supplementation and prevention of birth defects. J Nutr 2002;132(8 Suppl):2356s-60s. Epub 2002/08/07. PubMed PMID: 12163692. [
DOI:10.1093/jn/132.8.2356S] [
PMID]
18. Duncan TM, Reed MC, Nijhout HF. The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model. Mol Nutr Food Res 2013; 57(4):628-36. [
DOI:10.1002/mnfr.201200125] [
PMID] [
PMCID]
19. Baggot PJ, Eliseo AJ, DeNicola NG, Kalamarides JA, Shoemaker JD. Organic acid concentrations in amniotic fluid found in normal and Down syndrome pregnancies. Fetal Diagn Ther 2008; 23(3):245-8. [
DOI:10.1159/000116749] [
PMID] [
PMCID]
20. Norwitz ER, Levy B. Noninvasive prenatal testing: the future is now. Rev Obstet Gynecol 2013;6(2):48-62. [
PMID] [
PMCID]
21. Shiefa S, Amargandhi M, Bhupendra J, Moulali S, Kristine T. First Trimester Maternal Serum Screening Using Biochemical Markers PAPP-A and Free β-hCG for Down Syndrome, Patau Syndrome and Edward Syndrome. Indian J Clin Biochem 2013; 28(1):3-12. [
DOI:10.1007/s12291-012-0269-9] [
PMID] [
PMCID]
22. Czeizel AE, Puho E. Maternal use of nutritional supplements during the first month of pregnancy and decreased risk of Down's syndrome: case-control study. Nutrition 2005;21(6):698-704; discussion 74. [
DOI:10.1016/j.nut.2004.10.017] [
PMID]
23. Hollis ND, Allen EG, Oliver TR, Tinker SW, Druschel C, Hobbs CA, et al. Preconception folic acid supplementation and risk for chromosome 21 nondisjunction: a report from the National Down Syndrome Project. Am J Med Genet A 2013; 161 a(3):438-44. [
DOI:10.1002/ajmg.a.35796] [
PMID] [
PMCID]
24. Tsuji A, Noguchi R, Nakamura T, Shibata K. Folic Acid Deficiency Does Not Adversely Affect Oocyte Meiosis in Mice. Journal of nutritional science and vitaminology.2016; 62(6):375-9. [
DOI:10.3177/jnsv.62.375] [
PMID]
25. Balduino Victorino D, de Godoy MF, Goloni-Bertollo EM, Pavarino ÉC. Genetic Polymorphisms Involved in Folate Metabolism and Maternal Risk for Down Syndrome: A Meta-Analysis. Dis Markers 2014; 2014:517504. [
DOI:10.1155/2014/517504] [
PMID] [
PMCID]
26. Coppedè F. The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects. Front Genet 2015; 6:223. [
DOI:10.3389/fgene.2015.00223] [
PMID] [
PMCID]
27. Cuckle HS. Primary prevention of Down's syndrome. Int J Med Sci 2005; 2(3):93-9. [
DOI:10.7150/ijms.2.93] [
PMID] [
PMCID]