Volume 18, Issue 6 (September 2020)                   Nursing and Midwifery Journal 2020, 18(6): 460-466 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

dabirmoghadam P, Yazdani N, Aghazadeh K, Jafari M, Sohrabpour S, Erfanian R. DETERMINATION OF THE PREVALENCE OF OCCULT NECK LYMPH NODE INVOLVEMENT IN PATIENTS WITH LARYNGEAL SQUAMOUS CELL CARCINOMA. Nursing and Midwifery Journal 2020; 18 (6) :460-466
URL: http://unmf.umsu.ac.ir/article-1-4151-en.html
1- Associate professor of otolaryngology, Tehran University of Medical sciences
2- Assistant professor of otolaryngology, Tehran University of Medical Sciences (Corresponding Author) , aghazadeh@sina.tums.ac.ir
Abstract:   (3941 Views)
Background & Aims: Squamous cell carcinoma (SCC) accounts for 85% of laryngeal cancers. In some cases, lymph nodes do not show any specific symptoms despite being involved by cancer. Previous studies showed that patients undergoing selective neck lymph node dissection (SND) had significantly lower recurrence rates. We investigated the prevalence of occult neck lymph node involvement in patients with laryngeal SCC, and this is an important step in performing targeted selective neck lymph node dissection (SND) in these patients. Materials & Methods: This is a descriptive, retrospective, cross-sectional study involving the clinical records of patients with laryngeal carcinoma referred to Amir Alam Hospital from 2012 to 2017. Clinical and radiologic data showed that 66 patients had laryngeal SCC and were in the N0 stage. This group of patients was considered as the statistical sample of the study. A number of patients with similar status were excluded because of incomplete case data. Data analysis was done with SPSS v.22 software. Results: Of the total number of patients 29(44%), were diagnosed with glottic cancer, 29 (44%) with supraglottic cancer and 8 (12%) with subglottic cancer. 26 (39.5%) of these patients had lymph node metastasis (occult metastasis approved by post-operative pathology report). No metastasis in lymph nodes was found in 40(60.5%) patients. Of the 66 targeted patients, only 13 underwent radiotherapy before surgery. Of the 26 patients who had lymph node metastasis, 11 were diagnosed with glottic cancer and 13 patients with supraglottic cancer and 2 cases with subglottic cancer. Conclusion: Considering the nearly 20% prevalence of occult lymph node metastasis in patients with laryngeal squamous cell carcinoma who are in the N0 stage, it is recommended to selectively excise the neck lymph nodes in addition to the tumor surgery as this will reduce the recurrence rate of the disease.
Full-Text [PDF 1935 kb]   (559 Downloads)    
Type of Study: Research | Subject: پزشکی

References
1. Gillenwater A, Papadimitrakopoulou V, Richards-Kortum R. Oral premalignancy: new methods of detection and treatment.Curr Onco Rep 2006;8:146-54. [DOI:10.1007/s11912-006-0050-4] [PMID] [PMCID]
2. Jerjes W, Upile T, Akram S, Hopper C. The Surgical Palliation of Advanced Head and Neck Cancer using photodynamic Therapy. Clin Oncol 2010;22:785-91. [DOI:10.1016/j.clon.2010.07.001] [PMID]
3. Vokes EE, Weichselbaum RR, Lippman SM, Hong WK. Head and neck cancer. N Engl J Med1993; 328(3):184-94. [DOI:10.1056/NEJM199301213280306] [PMID]
4. Schantz SP, Yu GP. Head and neck cancer incidence trends in young Americans,1973-1997,with a special analysis for tongue cancer. Arch Otolaryngol Head Neck Surg 2002; 128(3):268-74. [DOI:10.1001/archotol.128.3.268] [PMID]
5. Vilaseca I, Blanch JL, Berenguer J, Grau JJ, Verger E, Muxí Á, et al. Transoral laser microsurgery for locally advanced (T3-T4a) supraglottic squamous cell carcinoma: Sixteen years of experience. Head Neck 2016;38(7):1050-7. [DOI:10.1002/hed.24408] [PMID]
6. Djordjevic V, Bukurov B, Arsovic N, Dimitrijevic M, Jesic S, Nesic V, et al. Prospective case-control study of efficacy of bilateral selective neck dissection in primary surgical treatment of supraglottic laryngeal cancers with clinically negative cervical findings (n0). Clin Otolaryngol 2016;41(6):634-9. [DOI:10.1111/coa.12570] [PMID]
7. Langroudi MM, Amirzargar B, Amali A, Sadeghi M, Jafar M, Hoseini MR, et al. Rate of Occult Cervical Lymph Node Involvement in Supraglottic Squamous Cell Carcinoma. Iranian journal of otorhinolaryngology 2017; 29(92):133-6. [] [PMCID]
8. Redaelli de Zinis LO, Nicolai P, Tomenzoli D, Ghizzardi D, Trimarchi M, Cappiello J, et al. The distribution of lymph node metastases in supraglottic squamous cell carcinoma: therapeutic implications. Journal for the Sciences and Specialties of the Head and Neck 2002;24(10):913-20. [DOI:10.1002/hed.10152] [PMID]
9. Dadas B, uslu B, Cakir B, Ozdogan HC. Intraoperative management of the thyroid gland in Iaryngeal cancer surgery. Otolaryngol Head Neck Surg 2001;30(3):179. [DOI:10.2310/7070.2001.20211] [PMID]
10. Petrovic Z, Jelic S, Pendjer I. Jugular neck dissection for supraglottic laryngeal carcinoma with negative clinical findings in the neck (N0). Srp Arh Celok Lek 2004, 132(3-4):73-5. [DOI:10.2298/SARH0404073P] [PMID]
11. Sanabria A, Shah JP, Medina JE, Olsen KD, Robbins KT, Silver CE, et al. Incidence of Occult Lymph Node Metastasis in Primary Larynx Squamous Cell Carcinoma, by Subsite, T Classification and Neck Level: A Systematic Review. Cancers2020; 12(4): 1059. [DOI:10.3390/cancers12041059] [PMID] [PMCID]
12. Sharbel DD, Abkemeier M, Groves MW, Albergotti WG, Byrd JK, Reyes-Gelves C. Occult Metastasis in Laryngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Ann Otol Rhinol Laryngol 2020; 3489420937744. [DOI:10.1177/0003489420937744] [PMID]
13. Jia S,He H,Xiang C,Liu W. Cervical metastasis in patients with T2-4 cN0 laryngeal carcinoma. Zhonghua Er Bi Yan Hou Ke Za Zhi 2004;39(1):24-7. [Google Scholar]
14. Mutlu V, Ucuncu H, Altas E, Aktan B. The Relationship between the Localization, Size, Stage and Histopathology of the Primary Laryngeal Tumor with Neck Metastasis. Eurasian J Med 2014; 46(1): 1-7. [DOI:10.5152/eajm.2014.01] [PMID] [PMCID]
15.  

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Nursing And Midwifery Journal

Designed & Developed by : Yektaweb