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  The effect of intravenous and oral iron administration on responsiveness to synthetic erythropoietin in treatment of hemodialysis patients' anemia     Shariati AR [1] , Asayesh H [2] , Mojerloo M [3] , Karimi Taleghani H [4]     Received: 10June, 2011 Accepted: August 28, 2011     Abstract   Background & Aims : Inadequate production of erythropoietin is the main cause of anemia in chronic kidney disease (CKD) patients and iron deficiency is the common cause of low response to synthetic erythropoietin in treatment of hemodialysis patients with anemia. This study was aimed to compare the effect of intravenous and oral iron administration on responsiveness to synthetic erythropoietin in increasing hemodialysis patients’ hemoglobin.   Materials & Methods: In this controlled single blind clinical trial, 42 hemodialysis patients with hemoglobin concentrations less than 10 mg/dl after seven weeks of treatment with 2000 unit's subcutaneous erythropoietin (three times a week after the end of each dialysis session) entered the study. After random allocation the patients were divided into two groups: oral iron supplementation (50 mg tablet as daily) was given to one and intravenous iron (100 mg three times a week after each dialysis session) for the other group. Finally, the dependent variables were measured again. The data were analyzed by t-test and paired t-test using SPSS software.   Results : The mean of hemoglobin and iron saturation was significantly increased in both groups (P

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